trazodone
Adjunctive therapy • Brands: DESYREL, OLEPTRO
Last reviewed: 2025-12-28
General information
- Class: Adjunctive therapy
- Common US brands: DESYREL, OLEPTRO
- Therapeutic drug monitoring not routinely recommended.
- Last reviewed: 2025-12-28
Dosing & forms
- Forms/strengths: —
- Frequency: —
- Food: —
- Typical range: —
Mechanism (brief)
Serotonin antagonist and reuptake inhibitor (SARI); 5-HT2 antagonism with weak SERT inhibition plus H1/α1 effects.
Metabolism & Half‑life
- Metabolism: CYP3A4
- Half‑life: Single-dose mean 7 h; Single-dose range 5–13 h
Therapeutic Drug Monitoring (TDM)
Recommended: No
Monitoring highlights
- —
Sources
- Trazodone hydrochloride prescribing information — DailyMed (2025)
- Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline — Journal of Clinical Sleep Medicine (2017)
- The efficacy and safety of trazodone for sleep problems in depressive patients — Psychopharmacology (2025)
- Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder — The Lancet (2018)