trimipramine
Adjunctive therapy • Brands: Surmontil
Last reviewed: 2025-12-30
General information
- Class: Adjunctive therapy
- Common US brands: Surmontil
- Therapeutic drug monitoring recommended; reference range 150–300 ng/mL.
- Last reviewed: 2025-12-30
Dosing & forms
- Forms/strengths: —
- Frequency: —
- Food: —
- Typical range: —
Mechanism (brief)
Tertiary-amine tricyclic antidepressant (TCA) with a sedating/anxiolytic clinical profile; mixed monoamine effects plus strong H1/α1/muscarinic antagonism.
Metabolism & Half‑life
- Metabolism: CYP2D6, CYP3A4
- Half‑life: Single-dose range 23–24 h
Therapeutic Drug Monitoring (TDM)
Recommended: Yes
Reference range: 150–300 ng/mL
Monitoring highlights
- —
Sources
- Trimipramine maleate capsules prescribing information — DailyMed (2025)
- Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017 — Pharmacopsychiatry (2018)
- APA Clinical Practice Guideline for the Treatment of Depression — American Psychiatric Association (2023)
- CANMAT 2024 Clinical Guidelines for Major Depressive Disorder — Canadian Journal of Psychiatry (2024)