Skip to content

Vilazodone

SSRI/5-HT1A partial agonist • Brands: Viibryd

Last reviewed: 2025-09-26

General information

Indicated for: Major depressive disorder.

Dosing & forms

  • Forms/strengths: —
  • Frequency: —
  • Food: —
  • Typical range: 20–40 mg once daily with food

Mechanism (brief)

Serotonin reuptake inhibitor and 5-HT1A receptor partial agonist.

Metabolism & Half‑life

  • Metabolism: Primarily CYP3A4, minor CYP2C19 and CYP2D6.
  • Half‑life: ~25 h.

Therapeutic Drug Monitoring (TDM)

Recommended: No

View labelExact

Monitoring highlights

  • Ensure administration with food to optimize absorption — Every visit initially
  • Monitor for GI intolerance (diarrhea, nausea) — During titration

Sources