vilazodone

General information

• Class: Adjunctive therapy
• Common US brands: Viibryd
• Typical dose range: Initiate 10 mg once daily with food for 7 days, increase to 20 mg once daily for 7 days, then advance to 40 mg once daily with food if tolerated.
• Therapeutic drug monitoring not routinely recommended.
• Last reviewed: 2026-02-22

Dosing & forms

• Forms/strengths: Film-coated tablets: 10 mg, 20 mg, 40 mg.
• Frequency: Initiate 10 mg once daily with food for 7 days, increase to 20 mg once daily for 7 days, then advance to 40 mg once daily with food if tolerated.
• Food: Take with food.
• Typical range: Initiate 10 mg once daily with food for 7 days, increase to 20 mg once daily for 7 days, then advance to 40 mg once daily with food if tolerated.

Mechanism (brief)

Serotonin reuptake inhibitor and 5-HT1A partial agonist.

Metabolism & Half‑life

• Metabolism: CYP3A4, CYP2C19 (minor), CYP2D6 (minor)
• Half‑life: Single-dose mean 25 h; Steady-state mean 25 h

Therapeutic Drug Monitoring (TDM)

Recommended: No

Sources

• Vilazodone hydrochloride tablets prescribing information — DailyMed (2023)
• Vilazodone in major depressive disorder: randomized, active and placebo-controlled trial — Cureus (2021)
• Comparative efficacy of antidepressant medication for adolescent depression: network meta-analysis — BMC Psychiatry (2025)
• Vilazodone for major depressive disorder: systematic review of efficacy and safety — International Journal of Clinical Practice (2012)
• Vilazodone, levomilnacipran and vortioxetine for major depressive disorder — International Journal of Clinical Practice (2015)