vortioxetine

Adjunctive therapy • Brands: Trintellix

Last reviewed: 2026-02-22

General information

Class: Adjunctive therapy
Common US brands: Trintellix
Typical dose range: Initiate 10 mg once daily; increase to 20 mg once daily after at least 7 days if tolerated.[label_vortioxetine]
Therapeutic drug monitoring not routinely recommended.
Last reviewed: 2026-02-22

Forms/strengths: Film-coated tablets: 5 mg, 10 mg, 15 mg, 20 mg.
Frequency: Initiate 10 mg once daily; increase to 20 mg once daily after at least 7 days if tolerated.[label_vortioxetine]
Typical range: Initiate 10 mg once daily; increase to 20 mg once daily after at least 7 days if tolerated.[label_vortioxetine]

Multimodal antidepressant: SERT inhibition plus 5-HT receptor modulation.

Recommended: No

Suicidality and psychiatric activation during initiation and dose changes, especially in younger adults.[label_vortioxetine]
Nausea and early GI tolerability during the first 1–2 weeks; supportive care and dosing time adjustments can prevent premature discontinuation.
Sodium in older adults or patients on diuretics if symptoms suggest hyponatremia (confusion, fatigue, falls).[label_vortioxetine]
Medication reconciliation for CYP2D6 inhibitors/inducers that can shift exposure and tolerability.[label_vortioxetine]
Mood elevation or mixed features in bipolar-spectrum illness; coordinate monitoring plans via the bipolar disorder hub.

Dosing & forms

Forms/strengths: Film-coated tablets: 5 mg, 10 mg, 15 mg, 20 mg.

Frequency: Initiate 10 mg once daily; increase to 20 mg once daily after at least 7 days if tolerated.[label_vortioxetine]

Typical range: Initiate 10 mg once daily; increase to 20 mg once daily after at least 7 days if tolerated.[label_vortioxetine]

Monitoring highlights

Suicidality and psychiatric activation during initiation and dose changes, especially in younger adults.[label_vortioxetine]

Nausea and early GI tolerability during the first 1–2 weeks; supportive care and dosing time adjustments can prevent premature discontinuation.

Sodium in older adults or patients on diuretics if symptoms suggest hyponatremia (confusion, fatigue, falls).[label_vortioxetine]

Medication reconciliation for CYP2D6 inhibitors/inducers that can shift exposure and tolerability.[label_vortioxetine]

Mood elevation or mixed features in bipolar-spectrum illness; coordinate monitoring plans via the bipolar disorder hub.