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Vortioxetine

Multimodal antidepressant • Brands: Trintellix

Last reviewed: 2025-09-26

General information

Indicated for: Major depressive disorder.

Dosing & forms

  • Forms/strengths: —
  • Frequency: —
  • Food: —
  • Typical range: 10–20 mg once daily

Mechanism (brief)

Serotonin transporter inhibition plus 5-HT receptor modulation (5-HT1A agonist, 5-HT1B partial agonist, 5-HT3/5-HT7 antagonist).

Metabolism & Half‑life

  • Metabolism: CYP2D6 primary, CYP3A4 and CYP2C19 contribute.
  • Half‑life: ~66 h.

Therapeutic Drug Monitoring (TDM)

Recommended: No

View labelExact

Monitoring highlights

  • Monitor for nausea and GI intolerance — During initiation
  • Assess for hyponatremia in older adults — Baseline and if symptomatic

Sources