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| Medication | Dosing highlights | Risk flags | LAI options |
|---|---|---|---|
amphetamine/dextroamphetamineAdjunctive therapyBrands: ADDERALL, ADDERALL XR, MYDAYIS View labelExact | Doses are typically started low and titrated gradually based on functional improvement and tolerability. Immediate-release products often require BID dosing; extended-release products are typically once daily in the morning.
Typical adult total daily dosing often falls in the 5–40 mg/day range, but labeled maxima vary by product and indication. | — | No |
methylphenidateAdjunctive therapyBrands: RITALIN, CONCERTA, DAYTRANA, METADATE CD, QUILLIVANT XR View labelExact | Adults (typical pattern): low morning dose with weekly titration based on benefit and tolerability; immediate-release products often need a noon dose, while extended-release products are typically once daily.
Typical adult total daily dosing varies by product. For extended-release (Concerta): 18–72 mg/day. Labeled maxima vary by product and delivery system; dose escalation that worsens sleep is typically avoided. A pretreatment evaluation including cardiac history, family history of sudden death, and assessment for tics/Tourette syndrome is recommended before initiation. If no improvement is observed within one month at appropriate doses, the medication should be discontinued. | — | No |
Usually once daily in the morning; afternoon/evening dosing is typically avoided due to insomnia risk.
Typical adult starting dose is 30 mg once daily, with titration in 10–20 mg steps (often weekly) based on response and tolerability. | — | No | |
Adults often start at 40 mg/day, then increase to a target of 80 mg/day after several days to weeks; maximum recommended dose is 100 mg/day (label). | — | No |
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