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| Medication | Dosing highlights | Risk flags | LAI options |
|---|---|---|---|
Typical initiation is at a low dose with weekly titration based on benefit and tolerability; immediate-release products are commonly BID, while extended-release products are usually once daily in the morning.
Typical daily doses are product- and age-dependent; labeled maximums vary by formulation (often about 20 mg/day for IR and 40 mg/day for ER). | — | No | |
methylphenidateAdjunctive therapyBrands: RITALIN, CONCERTA, DAYTRANA, METADATE CD, QUILLIVANT XR View labelExact | Adults (typical pattern): low morning dose with weekly titration based on benefit and tolerability; immediate-release products often need a noon dose, while extended-release products are typically once daily.
Typical adult total daily dosing varies by product. For extended-release (Concerta): 18–72 mg/day. Labeled maxima vary by product and delivery system; dose escalation that worsens sleep is typically avoided. A pretreatment evaluation including cardiac history, family history of sudden death, and assessment for tics/Tourette syndrome is recommended before initiation. If no improvement is observed within one month at appropriate doses, the medication should be discontinued. | — | No |
amphetamine/dextroamphetamineAdjunctive therapyBrands: ADDERALL, ADDERALL XR, MYDAYIS View labelExact | Doses are typically started low and titrated gradually based on functional improvement and tolerability. Immediate-release products often require BID dosing; extended-release products are typically once daily in the morning.
Typical adult total daily dosing often falls in the 5–40 mg/day range, but labeled maxima vary by product and indication. | — | No |
Adults often start at 40 mg/day, then increase to a target of 80 mg/day after several days to weeks; maximum recommended dose is 100 mg/day (label). | — | No |
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