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Max 4 meds. Sources include DailyMed labels; verify against official labeling. Last reviewed shown per row. On small screens the table defaults to a compact view—use “Show all columns” to view everything (scroll horizontally). Visit individual drug pages for narratives, printable summaries, and therapeutic drug monitoring notes.

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Oral Antipsychotics

Second Generation Antipsychotics (SGAs)

First Generation Antipsychotics (FGAs)

Long‑acting Injectable Antipsychotics (LAIs)

Mood Stabilizers

Adjunctive Medications

Ketamine & rapid-acting antidepressants (2)

Benzodiazepines (12)

Sleep & circadian agents (14)

ADHD & wakefulness agents (14)

Substance use treatment & harm reduction (11)

Metabolic & weight management (4)

Other adjunctive medications (17)

Compact view hides Indications, MOA, PK, TDM, Monitoring, and Reviewed.

Medication	Indications (label)	Dosing highlights	MOA	PK	TDM	Risk flags	Monitoring	LAI options	Last reviewed
promethazineAdjunctive therapyBrands: PHENERGAN View labelExact	Allergy symptoms, nausea/vomiting, motion sickness, and sedation (label; product-dependent). View labelExact	Dosing is indication-dependent (allergy vs nausea vs motion sickness vs sedation). Labels emphasize using the smallest dose adequate to relieve symptoms (label). Sedation labeling includes bedtime dosing (e.g., 25–50 mg in adults, product-dependent). Next-day impairment can occur; avoid stacking with other sedatives when possible (label/class).	Sedating first-generation antihistamine (H1 antagonist) and phenothiazine derivative with anticholinergic/antiemetic properties; used for allergy symptoms, nausea, motion sickness, and sedation.	Hepatic	No	Sedation	Sedation and next-day impairment (driving safety, falls risk). Respiratory depression risk when combined with other depressants or in sleep apnea. Anticholinergic effects (constipation, urinary retention, blurred vision) and delirium risk. Abnormal movements or rigidity/fever suggesting EPS or rare NMS.	No	2025-12-30
hydroxyzineAdjunctive therapyBrands: VISTARIL, ATARAX View labelExact	Anxiety symptoms (label); pruritus; pre/postoperative sedation (label varies by product). View labelExact	Anxiety/acute distress (off label patterns vary): 25–50 mg every 6–8 hours as needed; consider 10–25 mg starting doses in older adults or high fall risk.	First-generation antihistamine (H1 antagonist) with sedating and anxiolytic effects; anticholinergic/antiemetic properties.	Hepatic	No	Sedation QTc	Sedation, falls, and driving impairment are often reassessed after initiation and during dose changes—especially in older adults. Anticholinergic effects (constipation, urinary retention, confusion) are commonly monitored; total anticholinergic burden is minimized when possible. QT risk: QT-prolonging co-medications and electrolytes are typically reviewed, and baseline ECGs are often considered when risk factors stack. If use becomes frequent, the diagnosis is often revisited and plans may shift toward long-term anxiety treatment rather than continued PRN escalation.	No	2025-12-28
diphenhydramineAdjunctive therapyBrands: BENADRYL View labelExact	Allergy symptoms (OTC labeling varies). Off-label use is common for insomnia and acute anxiety-related distress (practice pattern). View labelExact	Allergy symptom dosing varies by product; one common pattern is 25–50 mg every 4–6 hours with a daily maximum (label varies).	First-generation antihistamine (H1 antagonist) with sedating and anticholinergic effects; commonly used OTC for allergies and as a sleep aid.	CYP2D6 \| Single-dose mean 9 h	No	Sedation	Sedation and next-day impairment (falls risk, driving safety). Anticholinergic effects (constipation, urinary retention, blurred vision). Confusion or delirium risk in older adults and polypharmacy (Beers). Duplicate diphenhydramine exposure from “PM” combination products.	No	2026-02-12
doxylamineAdjunctive therapyBrands: UNISOM View labelExact	OTC sleep aid (product-dependent). Also used in combination with pyridoxine for nausea/vomiting of pregnancy (label; product-dependent). View labelExact	OTC sleep aid labeling is product-dependent; one common direction is 25 mg once nightly about 30 minutes before bed.	First-generation antihistamine (H1 antagonist) with sedating and anticholinergic effects; OTC sleep aid and antiemetic ingredient (doxylamine/pyridoxine).	Hepatic \| Single-dose mean 10 h; Single-dose range 10–15 h	No	Sedation	Sedation and next-day impairment (falls risk, driving safety). Anticholinergic effects (constipation, urinary retention, blurred vision). Confusion or delirium risk in older adults and polypharmacy (Beers). Avoid duplicate sedatives and document a stop plan if nightly use develops.	No	2025-12-30

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