| Attention-deficit/hyperactivity disorder (ADHD) in patients 6 years and older (label). View labelExact | Pediatric ages 6–11: start 100 mg once daily; titrate by 100 mg weekly to a maximum of 400 mg once daily (label). | Nonstimulant ADHD medication (viloxazine extended-release) that modulates norepinephrine signaling; carries a boxed warning for suicidal thoughts/behaviors and is a strong CYP1A2 inhibitor with clinically important drug interactions. | CYP2D6, UGT1A9, UGT2B15 | Single-dose mean 7 h | No | | - Suicidal thoughts and behaviors monitoring during initiation and dose changes (boxed warning; label).
- Blood pressure and heart rate assessment at baseline, after dose increases, and periodically (label).
- Appetite/weight and sleep monitoring, especially in pediatric patients (clinical).
- Drug interaction review focused on CYP1A2 substrates and narrow-therapeutic-range agents (label).
| No | 2026-02-23 |
|---|
| Attention-deficit/hyperactivity disorder (ADHD). View labelExact | Adults often start at 40 mg/day, then increase to a target of 80 mg/day after several days to weeks; maximum recommended dose is 100 mg/day (label). | Selective norepinephrine reuptake inhibitor (non-stimulant ADHD medication). | CYP2D6 (major), CYP2C19 (minor) | Single-dose range 5–24 h | No | — | - Mood and suicidality monitoring in children/adolescents (boxed warning), especially early in treatment.
- Baseline and periodic blood pressure and heart rate (more often during titration).
- Appetite and weight tracking in children; consider growth monitoring when long-term.
- Fatigue/insomnia monitoring; dose timing or split dosing adjustments can help when limiting.
- Medication changes that affect CYP2D6 are worth reviewing when response or side effects change.
| No | 2026-02-23 |
|---|
| Attention-deficit/hyperactivity disorder (ADHD) (extended-release formulation; product-dependent). View labelExact | Typically once daily. Morning dosing is common, but bedtime dosing can be considered when sedation is prominent.
Dosing typically starts low and titrates weekly as tolerated. Typical doses are 1–4 mg/day (product- and age-dependent). | Alpha-2A adrenergic agonist (non-stimulant ADHD medication). | CYP3A4 | Single-dose mean 17 h; Single-dose range 10–30 h | No | | - Baseline and periodic blood pressure and heart rate, especially during titration.
- Sedation, dizziness, and orthostasis are commonly monitored; dose timing and titration speed are adjusted as needed.
- Interacting medications (CYP3A4 inhibitors/inducers) and other sedatives are typically reviewed.
- Taper planning in advance can reduce rebound hypertension and irritability.
| No | 2025-12-29 |
|---|
| Attention-deficit/hyperactivity disorder (ADHD); binge eating disorder in adults (product-dependent). View labelExact | Usually once daily in the morning; afternoon/evening dosing is typically avoided due to insomnia risk.
Typical adult starting dose is 30 mg once daily, with titration in 10–20 mg steps (often weekly) based on response and tolerability. | Prodrug stimulant converted to dextroamphetamine; increases dopamine and norepinephrine signaling. | Enzymatic hydrolysis (blood) to dextroamphetamine | Single-dose mean 11 h | No | — | - Baseline and periodic blood pressure and heart rate (more often during titration).
- Appetite and weight/BMI are tracked; nutrition and meal timing are revisited if weight loss occurs.
- Sleep onset and duration are monitored; timing adjustments are often tried before adding sedatives.
- Anxiety, agitation, mood elevation, or hallucinations are monitored; if concerning symptoms emerge, discontinuation and reassessment are common.
- Misuse/diversion risk is reviewed and safe storage counseling is documented.
| No | 2026-02-20 |
|---|