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Max 4 meds. Sources include DailyMed labels; verify against official labeling. Last reviewed shown per row. On small screens the table defaults to a compact view—use “Show all columns” to view everything (scroll horizontally). Visit individual drug pages for narratives, printable summaries, and therapeutic drug monitoring notes.

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Oral Antipsychotics

Second Generation Antipsychotics (SGAs)

First Generation Antipsychotics (FGAs)

Long‑acting Injectable Antipsychotics (LAIs)

Mood Stabilizers

Adjunctive Medications

Ketamine & rapid-acting antidepressants (2)

Benzodiazepines (12)

Sleep & circadian agents (14)

ADHD & wakefulness agents (14)

Substance use treatment & harm reduction (11)

Metabolic & weight management (4)

Other adjunctive medications (17)

Compact view hides Indications, MOA, PK, TDM, Monitoring, and Reviewed.

Medication	Indications (label)	Dosing highlights	MOA	PK	TDM	Risk flags	Monitoring	LAI options	Last reviewed
vortioxetineAdjunctive therapyBrands: Trintellix View labelExact	Major depressive disorder. View labelExact	Initiate 10 mg once daily; increase to 20 mg once daily after at least 7 days if tolerated.[label_vortioxetine]	Multimodal antidepressant: SERT inhibition plus 5-HT receptor modulation.	CYP2D6, CYP3A4, CYP2C19 \| Single-dose mean 66 h; Steady-state mean 66 h	No	—	Suicidality and psychiatric activation during initiation and dose changes, especially in younger adults.[label_vortioxetine] Nausea and early GI tolerability during the first 1–2 weeks; supportive care and dosing time adjustments can prevent premature discontinuation. Sodium in older adults or patients on diuretics if symptoms suggest hyponatremia (confusion, fatigue, falls).[label_vortioxetine] Medication reconciliation for CYP2D6 inhibitors/inducers that can shift exposure and tolerability.[label_vortioxetine] Mood elevation or mixed features in bipolar-spectrum illness; coordinate monitoring plans via the bipolar disorder hub.	No	2025-10-05
vilazodoneAdjunctive therapyBrands: Viibryd View labelExact	Major depressive disorder. View labelExact	Initiate 10 mg once daily with food for 7 days, increase to 20 mg once daily for 7 days, then advance to 40 mg once daily with food if tolerated.	Serotonin reuptake inhibitor and 5-HT1A partial agonist.	CYP3A4, CYP2C19 (minor), CYP2D6 (minor) \| Single-dose mean 25 h; Steady-state mean 25 h	No	—	Monitor clinical response, adverse effects, and interactions; see the drug page for details.	No	2025-12-29
duloxetineAdjunctive therapyBrands: Cymbalta View labelExact	Major depressive disorder; generalized anxiety disorder; diabetic peripheral neuropathic pain; fibromyalgia; chronic musculoskeletal pain. View labelExact	Major depressive disorder (clinical depression) and generalized anxiety disorder: typical initiation is 30 mg once daily for one week for tolerability, then 60 mg once daily. If needed, 90–120 mg/day is sometimes used (divide when >60 mg/day), though antidepressant benefit often plateaus beyond 60 mg/day.	Serotonin-norepinephrine reuptake inhibitor (SNRI).	CYP1A2, CYP2D6 \| Single-dose mean 12 h; Single-dose range 8–17 h; Steady-state mean 12 h	No	—	Blood pressure and heart rate at baseline and periodically, especially during titration and at higher doses. Liver-injury symptoms (jaundice, dark urine, abdominal pain, pruritus), particularly in patients with alcohol use disorder or hepatic disease; LFTs are obtained when clinically indicated. Sodium in older adults or diuretic users if symptoms suggest hyponatremia (confusion, fatigue, falls). Medication reconciliation for serotonergic combinations and for CYP2D6 substrates (TCAs, antipsychotics, beta-blockers, tamoxifen).	No	2025-10-05

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